Macrophage integrins modulate response to ultra-high molecular weight polyethylene particles and direct particle-induced osteolysis
نویسندگان
چکیده
منابع مشابه
Preparation of Ultra High Molecular Weight Polyethylene Using Ziegler-Natta Catalyst System: Optimization of Parameters by Response Surface Methodology
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An In Vivo Model of Continuous Infusion of Ultra High Molecular Weight Polyethylene Particles
Introduction: Wear particles from orthopaedic implants have been shown to affect both initial osseointegration and subsequent bone remodeling of total joint replacements (TJRs). Continued production and exposure to particles over time adversely affects bone formation and resorption, resulting in periprosthetic osteolysis. Current animal models of particle-induced periprosthetic osteolysis have ...
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Nanometre-sized particles of ultra-high molecular weight polyethylene have been identified in the lubricants retrieved from hip simulators. Tissue samples were taken from seven failed Charnley total hip replacements, digested using strong alkali and analysed using high-resolution field emission gun-scanning electron microscopy to determine whether nanometre-sized particles of polyethylene debri...
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Substantially reducing the rate of generation of wear particles at the surfaces of ultra-high-molecular-weight polyethylene (UHMWPE) orthopedic implant bearing components, in vivo, is widely regarded as one of the most formidable challenges in modern arthroplasty. In the light of this, much research attention has been paid to the myriad of endogenous and exogenous factors that have been postula...
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2017
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2016.10.038